Science and its epistemology have been challenged by science-related populism—a variant of populism suggesting that a virtuous “ordinary people,” and not allegedly corrupt academic elites, should determine the “production of truth.” Yet almost no studies have assessed the prevalence of science-related populist attitudes among the population and explanatory factors thereof. Based on a nationally representative survey in Switzerland, our study shows that only a minority of the Swiss exhibit science-related populist attitudes. Comparisons with reference studies suggest that these attitudes may be less prevalent in Switzerland than political populist attitudes. Those who hold stronger science-related populist attitudes tend to have no university education, less personal contact with science, lower scientific literacy, and higher interest in science. Additional analyses show that left-leaning citizens are less likely to hold science-related populist attitudes than moderate and right-leaning citizens. Our findings contribute to current debates about a potential fragmentation of science communication audiences and call for further research on the sociodemographic and attitudinal profiles of people with skeptical orientations toward science.